ANS 426: Mammalian Endocrinology

Instructor:		Dr. Todd A. Winters
			Office:  Ag. 127/111
			Phone:  453-1760
			Email: tw3a@siu.edu
				
Teaching Assistant:	Other Faculty, Staff, and/or
			Graduate Students may
			occasionally guest lecture.

Office Hours: 		MWRF 8-9; MW 2-3 
			or by appointment or availability

Text:			Hadley, 2000, Endocrinology, 5th Edition

Other Reference:	Alberts et al., 1994, Molecular Biology of the Cell, 3rd Edition

Webpage:		http://www.siu.edu/~tw3a/426.htm 
			(Contains course notes and other course information and materials)

Time & Place:		1 to 1:50, MWF
			Ag. 152

Learning Objectives:

1.	Understand the comparative effects of hormones on target tissues.

2.	Understand the biochemistry of hormone biosynthesis.

3.	Understand the mechanisms of hormone release and transport.

4.	Understand the mechanisms of hormone receptor kinetics and signal transduction

5.	Understand how hormones, receptors, and signal transduction are measured and studied.

6.	Understand endocrine-related diseases and disorders.

Grading:	

Quizzes: Twelve 10 pt. quizzes will be given during the first 10 minutes of each 
Friday covering material from the lectures and labs from the previous week since 
the last quiz.  The lowest two quizzes will be dropped.  Quizzes can not be made up.  
A missed quiz will be counted as a dropped quiz.

Exams: Three Mid-terms (Sept 23 [study guide], Oct 19 [study guide], Nov 18 [study guide]) 
and a Final Exam will be given in the course.  Make-up exams will be essay or oral 
at the instructors' discretion.  20% will be taken off the top of any make-ups 
given to students who do not notify an instructor before the regularly 
scheduled exam.  The Final will be Thursday, December 15, 10:10 to 12:10 PM (75% comprehensive).   
The final will only be given at the scheduled time--no make-ups or early exams.  Students 
that do not take the final will be given "0" on the final or an incomplete depending 
on the circumstances determined by the instructor.

Extra Credit: Midterm exam grades can be increased by up to 5 points each by 
turning in a scientific paper summary within 1 week of the day that exams 
are returned.  Summaries are to be obtained from a scientific paper published
in 2004 or 2005 from the journals Endocrinology, Molecular Endocrinology, or
The Journal of Clinical Endocrinology and Metabolism.  The summaries should not exceed 
2 pages and should include the journal reference, introduction, methods, 
results, and discussion.  Do not plagiarize!  Extra credit opportunities 
will also show up occasionally on the course webpage.  Extra credit will 
also be given for certain endocrinology-related seminars or related events on campus.  
All extra credit will be added to midterm exam scores.
Extra Credit is often given for attendance when the majority of the class is absent.

Participation: A subjective grade will be given based on participation in lectures.  
Points will also be removed for disruptive behavior.

Incompletes: Incompletes will only be given in special cases with written endorsement 
from a medical professional or university official.  Failing the course is not a reason 
for receiving an incomplete on its own.  If a student takes an incomplete they will 
normally have to take the whole course over.

Grading Breakdown:	 20% 	Quizzes			A=90 to 100%
			 50% 	3 Midterm Exams		B=80 to 89%
			  5%    Participation		C=70 to 79%
			 25%	Final Exam		D=60 to 69%
			100%	Total			F=<60%
									
					
The instructor reserve the right to lower the curve as appropriate.  The curve will not 
be raised.  Graduate students will be not be included in the undergraduate student curve.

ANS 426 Lectures

Order    		Lecture Topic               	Reading                     	
1.		Hormones, History, and Homeostasis	Syllabus/Ch. 1
2.		Endocrine System			Ch. 2
3.		Endocrine Methodologies			Ch. 3
4.		Mechanisms of Hormone Action:		Ch. 4, Alberts et al., Ch. 15
			Part 1, Part 2				
5.		Eicosinoids				Ch. 4
6.		Anterior Pituitary Hormones		Ch. 5/8
			Part 1, Part 2
7.		Hypothalamus Endocrinology		Ch. 6
			Part 1, Part 2	
8.		Neurohypophyseal Hormones		Ch. 7
9.		Endocrinology of Calcium Homeostasis	Ch. 9
10.		Gastrointestinal Hormones		Ch. 10
11.		Pancreatic Hormones and Metabolism	Ch. 11
12.		Growth Hormones				Ch. 12
			Part 1, Part 2
13.		Thyroid Hormones			Ch. 13
14.		Adrenal Medulla Hormones		Ch. 14
15.		Adrenal Steroid Hormones		Ch. 15
16.		Reproductive Endocrinology		Ch. 16/17/18/19/20
17.		Neurohormones				Ch. 21

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~~~~~Revised 8/22/05~~~~~ TAW