The overall objective of these studies are to investigate the role of soy protein and/or phytoestrognes in effecting cardiovascular risk factors, especially insulin resistance.
Questions:
1. Does soy protein and/or genistein alleviate or exacerbate symptoms associated with insulin resistance?
2. Does soy protein and/or genistein modulate insulin-stimulated glucose transport, glucose transporter (GLUT4) levels, and tyrosine kinase activity in and insulin sensitive and insulin resistant animal model?
3. Does genistein modulate insulin-stimulated glucose transport, glucose transporter (GLUT4) levels, and tyrosine kinase activity in tissue culture cells derived from skeletal muscle and adipocytes
4. What are the systemic effects of ingested phytoestrogens and soy protein on pigs and rats as related to cardiovascular health.
