Soy Phytoestrogens:
Effects on Physiology and Health

T.A. Winters and W.J. Banz

(and Collaborators)


Publications/Presentations:

Winters, T. A., J. A. Greer, S. R. Read, M. P. Williams, A. M. Suttner, G. A. Byassee, M. L. Doran, D. A. Lightfoot, and W. J. Banz. 1997. Dietary soy protein and phytoestrogens: A histological examination of reproductive tissues in rats. Symposium on Phytoestrogen Research Methods: Chemistry, Analysis, and Biological Properties. Tuscon, AZ. September 23.

Lightfoot, D., V. Nitji, W. J. Banz, and T. A. Winters. 1997. Genetic Analysis of phytoestrogen content in soybeans. Symposium on Phytoestrogen Research Methods: Chemistry, Analysis, and Biological Properties. Tuscon, AZ. September 23.

Banz, W. J., M. P. Williams, J. A. Greer, S. R.. Read, G. A. Byassee, D. A. Lightfoot, T. A. Winters. 1997. The effects of soy protein and soy phytoestrogens on symptoms associated with cardiovascular disease in rats. Symposium on Phytoestrogen Research Methods: Chemistry, Analysis, and Biological Properties. Tuscon, AZ. September 23.

Suttner, A., N.A. Danilovich, W.J. Banz, and T.A. Winters. 1998. The effects of the phytoestrogen daidzein on in situ apoptosis in primary porcine granulosa cells. Biol. Reprod. 58 (Suppl.1): 74

Carnevale, E.M., M. Uson, B.L. Soderstrom, J.J. Crawford, and T.A. Winters. 1998. Effects of phytoestrogens on the reproductive tract of anestrous mares. Annual Meeting of The Society for Theriogenology and the American Association of Equine Practitioners Convention, Baltimore, Md., December 6-9.

Lightfoot, D.A., T.A. Winters, V. Njiti, and W.J. Banz. 1999. Genetic analysis of phytoestrogen content in soybeans and animal diets. International Plant and Animal Genome Conference VII, San Diego, CA. Jan. 17-21. Poster # 66 (http://www.intl-pag.org/pag/7/abstracts/pag7675.html)

Banz, W., M. Peluso, T. Winters, and M. Shanahan. 1999. The effects of soy protein and isoflavones on platelet, lipid, and liver measurements in Zucker rats. Annual (FASEB) Experimental Biology Meeting, Washington, D.C. April 20. Abstract 669.7, pg. A885.

Wilson, T., H. March, W.J. Banz, Y. Hou, S. Adler, C.Y. Meyers, T.A. Winters, and M.A. Maher. 1999 Antioxidant effects of phyto- and synthetic estrogens on Cu++-induced oxidation of human low density lipoproteins (LDL). Annual (FASEB) Experimental Biology Meeting, Washington, D.C. April 20. Abstract 676.13, pg. A905.

Winters, T.A, W.J. Banz, M.A. Mallon, and S. Adler. 1999. Estrogenic gene activation and estrogenic gene repression by phytoestrogens define two functional classes. Proceedings of the Sixth World Soybean Research Conference, Global Soy Forum 99, Chicago, IL, Aug. 7, pg. 710.

Njiti, V.N, W.J. Banz, K. Ogg, D. Hyten, K. Meksem, J. Juas, D.A. Lightfoot, and T.A. Winters. 1999. Molecular markers associated with phytoestrogen production in soybeans. Proceedings of the Sixth World Soybean Research Conference, Global Soy Forum 99, Chicago, IL, Aug.5, pg. 442.

Raymer, A.M., N.A. Hoefling, W.J. Banz, and T.A. Winters. 1999. Soy isoflavones: Effects on in situ apoptosis in swine ovarian granulosa cells. Proceedings of the Sixth World Soybean Research Conference, Global Soy Forum 99, Chicago, IL, Aug.7, pg. 686.

Banz, W, S. Hauck, B. Gename, A. Bartke, and T. Winters. 1999. The effects of the soy phytoestrogens genistein and daidzein on liver function and cardiovascular health. Proceedings of the Sixth World Soybean Research Conference, Global Soy Forum 99, Chicago, IL, Aug.7, pg. 707.

Peluso, M., M. Williams, M. Hagemeyer, R. Steger, T. Winters, M. Shanahan, and W. Banz. 1999. Soy protein rich in isoflavones modulates hepatic neutral lipids and blood platelet sensitivity in rats. Proceedings of the Sixth World Soybean Research Conference, Global Soy Forum 99, Chicago, IL, Aug.7, pg. 716.

Greer-Baney, J.A., W.J. Banz, D.A. Lightfoot, and T.A. Winters. 1999. Dietary soy protein and soy isoflavones: A histological examination of reproductive tissues in rats. J. Med. Food 2(3-4):247-249.

Njiti, V.N., K. Meksem, J. Yuan, W.J. Banz, D.A. Lightfoot and T.A. Winters. 1999. DNA markers associated with loci underlying seed phytoestrogen content in soybeans. J. Med. Food 2(3-4):185-187.

Banz, W. J., M. P. Williams, D.A. Lightfoot, and T.A. Winters. 1999. The effects of soy protein and soy phytoestrogens on symptoms associated with cardiovascular disease in rats. J. Med. Food 2(3-4):271-273.

Banz, W., R. Steger, M. Roeder, M. Peluso, C. Stiglitz, B. Kinney, T. Winters, and M. Shanahan. 2000. High isoflavone soy protein ameliorates impaired glucose tolerance and fatty liver in female Zucker obese rats. Annual (FASEB) Experimental Biology Meeting, San Diego, CA, April 18, Abstract 528.7. FASEB J. 14(4):A765

Meksem, K, V.N. Njiti, W.J. Banz, D.A. Lightfoot, M.J. Iqbal, A.M. Kassem, D.J. Hyten, J. Yuan, and T.A. Winters. 2000. Genomic regions that underlie soybean seed isoflavone content. International Plant and Animal Genome Conference VIII, San Diego, CA. Jan. 9-12. Poster Abstract # 297 (http://www.intl-pag.org/pag/8/abstracts/pag8759.html)

Peluso, M., T.A. Winters, M.F. Shanahan, and W.J. Banz. 2000. A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats. J. Nutr. 130:2333-2342.

Hoefling, N.A., A.M Raymer, W.J. Banz, A. Bartke, and T.A. Winters. 2000. Soy isoflavones effects on porcine granulosa cell apoptosis are estrogen mediated. 21st Annual Minisymposium of Reproductive Biology. Center for Reproductive Sciences, Northwestern University, Evanston, IL, Oct. 16., Abstract #21.

Banz, W., M. Iqbal, R. Steger, M. Roeder, M. Peluso, C. Stiglitz, B. Kinney, T. Winters, M. Shanahan, and D. Lightfoot. 2000. High isoflavone soy protein alters genes involved in glucose and lipid metabolism in obese rats. 8th Biennial Conference on the Cellular and Molecular Biology of the Soybean (SOY2000), Lexington, KY, August 15, pg. PII 10.

Njiti, V, A. Kaseem, J. Yuan, K. Meksem, M. Schmidt, W.J. Banz, T.A. Winters, and D. Lightfoot. 2000. Genetic analysis of phytoestrogen content in soybeans. 8th Biennial Conference on the Cellular and Molecular Biology of the Soybean (SOY2000), Lexington, KY, August 15, pg. PII 9.

Kassem, M.A., K. Meksem, M.J. Iqbal, V. Njiti, W.J. Banz, T.A. Winters. 2001. QTL that underlie soybean seed isoflavone content. International Plant and Animal Genome Conference IX, San Diego, CA. Jan. 13-17. Poster Abstract #270 (http://www.intl-pag.org/pag/9/abstracts/P3b_38.html).

Iqbal, M.J., W. Banz, R. Steger, M. Roeder, M. Peluso, C. Stiglitz, B. Kinney, T. Winters, M. Shanahan, and D. Lightfoot. 2001. Diets containing high isoflavone soy protein alter expression of key genes in obese rats. International Plant and Animal Genome Conference IX, San Diego, CA. Jan. 13-17. Poster Abstract #209. (http://www.intl-pag.org/pag/9/abstracts/P07_14.html).

Meksem, K., V.N. Njiti, W.J. Banz, J. Iqbal, M.M. Kassem, D. Hyten, J. Yuang, T.A. Winters, and D.A. Lightfoot. 2001. Genomic regions that underlie soybean seed phytoestrogen content. J. Biomed. Biotechnol. 1(1):38-45 (http://jbb.hindawi.com/volume-1/S1110724301000110.html).

Peluso, M., N. Moretz, C. Wright, N. Henry, M. Roeder, T. Winters, M. Shanahan, W. Banz, and A. Bartke. 2001. Liver and plasma lipids in human GH transgenic mice fed lab chow and semipurified diets containing casein or soy protein. 83rd Annual Meeting of the Endocrine Society, Denver, CO, June 20-23.

Hagemeyer, M., W. Banz, T. Winters, and M. Shanahan. 2001. Differential effects of phytoestrogens and estrogens on platelet reactivity. Abstract 500.3. FASEB J. 15(4):A631..

Carroll, B., M. Roeder, T. Winters, G. Apgar, M. Peluso, M. Hagemeyer, M. Shanahan, M. Bonkowski, W Banz. 2001. The Effects of Low- and High-Isoflavone Soy-Protein Diets on Platelet Aggregation and Physiological and Biochemical Parameters in Boars. Abstract 500.2. FASEB J. 15(4):A631.

Banz, W.J., M.J. Iqbal, R. Ahsan, T.A. Winters, and D.A. Lightfoot. 2001. The Effect of High- and Low-Isoflavone Soy Protein Diets on Gene Expression in Lean and Obese Rats. Abstract 500.7. FASEB J. 15(4):A632.

Wilson, T., H. March, W.J. Banz, Y. Hou, S. Adler, C.Y. Meyers, T.A. Winters, and M.A. Maher. 2002. Antioxidant effects of phyto- and synthetic estrogens on cupric ion-induced oxidation of human low density lipoproteins in vitro. Life Sci. 70:2287-2298.

Kassem, M.A, K. Meksem, W.J. Banz, T.A. Winters, and D.A. Lightfoot. 2003. Two additional QTLs for isoflavone content in a soybean recombinant inbred line population of Essex X Forrest. International Plant and Animal Genome Conference XI, San Diego, CA. Jan. 11-15. Poster Abstract #902 (http://www.intl-pag.org/11/abstracts/P3b_P902_XI.html).

Mezei, O., W.J. Banz, R.W. Steger, M.R. Peluso, T.A. Winters, and N. Shay. 2003. Soy isoflavones exert anti-diabetic and hypolipidemic effects via the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J. Nutr. 133:1238-1245.  

Acuna, G., N. Moretz, K.J. Miller, T.C. Headrick, W.J. Banz, A. Bartke, and T.A. Winters. 2003. Effects of Soy Isoflavones on the Uterine Composition of Aged Female Mice. Abstract #437. Biol. Reprod. 68(Suppl. 1):292. 

Bonkowski, M, N. Moretz,, C. Wright, W. Banz, T. Winters, and A. Bartke. 2003. The effects of soy protein and soy isoflavones on longevity in various models of aging in mice. Abstract #200.4, FASEB. J. 17(4, Part 1):A330. 

Sellitto, A.D, D.W. Lietner, G.A. Apgar, and T.A. Winters. 2003. The effect of soy phytosterols on porcine granulosa cell apoptosis. Abstract #278. Biol. Reprod. 68(Suppl. 1):227.

Acuna, G., N. Moretz, W.J. Banz, A. Bartke, and T.A. Winters. 2003. The effects of soy isoflavones on glucose tolerance in aged female mice. Abstract #197.4, FASEB. J. 17(4, Part 1):A322. 

Harty, J, K. Jones, W. Banz, T. Winters, and M. Roeder. 2003. The effect of soy phytoestrogens on cultured skeletal and smooth muscle cells. Abstract #693.13, FASEB. J. 17(4, Part 2):A1111.

Sellitto, A.D, D.W. Lietner, G.A. Apgar, and T.A. Winters. 2003. The effect of soy bioactive compounds on porcine granulosa cell apoptosis. Proceedings of the 9th Annual Southern Illinois University Molecular and Cellular Biology Symposium, Pere Marquette Lodge, Grafton, IL, Mar. 28, Oral Presentation Abstract, pg. 4. 

Kassem, M.A, K. Meksem, M.J. Iqbal, V.N. Njiti, T.A. Winters, W.J. Banz, A.J. Wood, and D.A. Lightfoot. 2004. Two additional QTLs that underlie soybean seed isoflavone content in a soybean recombinant inbred line population of Essex X Forrest. International Plant and Animal Genome Conference XII, San Diego, CA. Jan. 10-14. Poster Abstract #541 (http://www.intl-pag.org/11/abstracts/P3b_P902_XI.html). 

Kassem, M.A., K. Meksem, V.N. Njiti, M.J. Iqbal, W.J. Banz, T.A. Winters, and D.A. Lightfoot. 2004. Definition of soybean genomic regions that control seed phytoestrogen amounts. J. Biomed. Biotechnol. 1:52-60.









~~~~~Revised 7/29/04~~~~~ TAW